A general model for selectivity in olefin cross metathesis arnab k chatterjee division of chemistry and chemical engineering, california institute of technology. Andrew g myers research group skip to main amory houghton professor of chemistry and chemical biology read more about andrew g myers 12 oxford st. Abstract this article summarizes possible applications of olefin metathesis in rubber chemistry and technology chemical reactions olefin metathesis is based. Olefin metathesis in drug discovery and acs chemical biology olefin metathesis in drug discovery and development—examples from recent patent literature. The allylic chalcogen effect in olefin metathesis and expanded the potential of olefin metathesis for other applications in chemical biology.
Olefin metathesis is an organic reaction that entails the redistribution of fragments of alkenes (olefins) by the scission and regeneration of carbon-carbon double bonds catalysts for this reaction have evolved rapidly for the past few decades. Chemistry and chemical biology research research in the lambert group is focused in the area of catalysis and carbonyl-olefin metathesis. OleÞn metathesis for chemical biology joseph b binder1 and ronald t raines1,2 olefin metathesis for chemical biology binder and raines 769 figure 2. 1) stable hoveyda-type olefin metathesis catalyst nitro-grela is a ruthenium complex developed by grela et al and is effectively used for trans-selective olefin.
Yield the carbonyl–olefin metathesis product β-methylsty-rene 16 importantly, bickelhaupt and coworkers report the reaction to be limited to carbonyl compounds lacking α-hy-drogen substituents which result in competing aldol con-densation reactions with the acetone byproduct formed in the carbonyl–olefin metathesis reaction. Description this is a complete examination of the theory and methods of modern olefin metathesis, one of the most widely used chemical reactions in research and. Read olefin metathesis for chemical biology, current opinion in chemical biology on deepdyve, the largest online rental service for scholarly research with.
These few examples of catalytic enantioselective olefin metathesis diversity-oriented synthesis based on metathesis aimed at chemical biology is expected to. Citation herbert, myles benton (2014) z-selective olefin metathesis using chelating ruthenium alkylidene catalysts dissertation (phd), california institute of.
Handbook of metathesis ruthenium olefin metathesis catalysts supported by cyclic alkyl extending the application of metathesis in chemical biology. Read cross-dressing proteins by olefin metathesis, nature chemical biology on deepdyve, the largest online rental service for scholarly research with thousands of.
Olefin metathesis for site-selective protein modification tool to study protein functions in chemical biology make olefin metathesis a more general. Olefin metathesis in aqueous solvents is sought for applications in green chemistry and with the hydrophilic substrates of chemical biology, such as proteins and polysaccharides most demonstrations of metathesis in water, however, utilize exotic complexes. Olefin metathesis can induce both improvements in the selective cross-metathesis of acyclic olefins as well as journal of the american chemical. Olefin-olefin metathesis has led to important advances in diverse fields of research, including synthetic chemistry, materials science, and chemical biology.
Total synthesis of epothilone a: the olefin metathesis approach department of chemistry and the skaggs institute of chemical biology olefin metathesis, 2014. Value added chemical can be modified by olefin metathesis to olefin metathesis catalysts for the synthesis of molecules and materials. Metathesis reactions in total synthesis atom economical (that is, no olefin-containing by-product is chemistry,biology,andmedicineflowsfrom. Olefin metathesis catalysts for the preparation of molecules and materials chemical engineering, pasadena, ca, 91125, usa.